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| List of Tables Preface (or, the Story of an Idea) 1 Introduction Definitions History 2 Central Pain of Brain Origin Epidemiology and clinical features 1. Lesions causing CP and location 2. Incidence and prevalence 3. Age of onset of CPSP 4. Sex distribution of CPSP 5. Time to pain onset 6. Side of the lesions 7. Size of the lesion and CPSP 8. Pain distribution 9. Quality of pain 10. Intensity of pain 11. Components 12. Evoked pains 13. Somatosensory findings 14. Sympathetic and other signs and symptoms Special considerations 1. Sensory epilepsy 2. Parkinson's disease (PD) 3. Iatrogenic lesions 3 Central Pain of Cord Origin 1. Lesions causing CCP 2. Incidence and prevalence 3. Age of onset and sex distribution 4. Time to pain onset 5. Level of lesion 6. Distribution of pain 7. Quality 8. Intensity 9. Components 10. Evoked pains 11. Somatosensory deficits 12. Sympathetic and other signs and symptoms 13. Course Special considerations 1. Syringomyelia 2. Multiple sclerosis (MS) 3. Spinal epilepsy 4 Diagnosing Central Pain 5 Drug Therapy Oral and parenteral drug therapy 1. General comments GABA drugs Antiglutamatergic agents Sodium channel blockers Antidepressants Opioids, naloxone and cannabinoids Miscellaneous agents Combinations 2. Drug aggravation of CP 6 Neuromodulation Electrical 1. Extra- and subdural motor (MCS) and sensory cortex stimulation (PCS) Mechanism of action 2. Deep brain stimulation (DBS) Mechanism of action a. PAG-PVG b. Vc c. Other areas Efficacy a. Vc DBS b. PAG-PVG DBS 3. Spinal cord stimulation Mechanism of action Efficacy …… 7 Pathophysiology:Human Data 8 Piecing Together the Evidence References Index |
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