最 低 价：￥568.80
定 价：￥632.00
作 者：AlisonStewart，PhilippaBrice，HilaryBurton，PaulPharoah，Simon Sanderson，Ron Zimmern 著 著
出版时间：2007-6-1
I S B N：9780521529075
| Foreword Acknowledgements 1 Introduction The definition of public health genetics Genetic and environmental factors as determinants of health Genetic disease，complex disease and the combined effects of genetic and environmental factors The emergence and development of public health genetics Advances in epidemiology and its application to public health The rise of genetic epidemiology The growth of genetic science The impetus for public health genetics Community genetics Attitudes to public health genetics An international public health genetics network：the Bellagio initiative About this book Further reading and resources Principles of public health The emergence of public health genetics The human genome project and‘genomic medicine’ Community genetics Current developments in public health genetics Genomics and global health 2 Genetic science and technology Basic molecular genetics Genes and the genome Chromosomas The‘central dogma’：DNA makes RNA makes Drotein Gene structure and expression in more detail The complexity of the genetic programme Genetic variation：mutation and polymorphism Cell division and the maintenance of the genome Miosis and recombination：the formation 0f sex cells Inheritance patterns Genes and disease Mendelian(‘single—gene’)diseases Mitochondrial disorders Chromosomal disorders Diseases caused by disorders in epigenetic mechanisms Mendelian subsets of common diseases MultifactoriaI disease Cancer Some complexities of the relationship between genes and djsease Penetrance Inherited and new mutations Genetic heterogeneity Variable expressivity Genetic technology Cutting and joining pieces of DNA Separating pieces of DNA in a mixture Detecting specific sequences：hybridisation Fluorescent in situ hybridisation(FISHl DNA cloning and clone libraries The polymerase chain reaction DNA sequencing DNA microarrays Markers and maps The human genome project Mapping human genetic variation：SNPs and haplotypes The post—genome challenge Identifying genes and studying gene function Proteomics Comparative genomics Bioinformatics Systems biology Epidemiological and biomedical informatics …… 3 Fundamentals of genetic epidemiology 4 Genetics in medicine 5 Genetics in health services 6 Ethical，legal and social implications of genetics 7 Policy implications Index |
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