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| 作者介绍：AHMED F. ABDEL-MAGID AHMED F. ABDEL-MAGID is a Senior Research Fellow in Chemical and Pharmaceutical Development at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. |
| Contributors. Preface. 1. Reflections on Process Research II 2. Development and Scale-Up of a Heterocyclic Cross-Coupling for the Synthesis of 5-[2-(3-Methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridine-7-yl] amino-2-methyl-1H-indole 3. Large-Scale Enantioselective Preparation of 2E,7E, 5S,6R,5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoic Acid, a Key Fragment for the Formal Total Synthesis of the Anti-tumor Agent Cryptophycin 52 4. Efforts Toward a Commercially Viable Route and Process to the Synthesis of HIV PI GW640385X 5. Development of an Asymmetric Synthesis of ABT-100 6. Asymmetric Hydrogenation: A New Route to Pregabalin 7. Responsibilities of the Process Chemist: Beyond Synthetic Organic Chemistry 8. Outsourcing—The Challenge of Science, Speed, and Quality 9. Automation and the Changing Face of Process Research in the Pharmaceutical Industry 10. Large-Scale Synthesis: An Engineering Perspective 11. Synthesis and Application of Radioisotopes in Pharmaceutical Research and Development 12. Selection of the Drug Form in Exploratory Development 13. Strategies to Achieve Particle Size of Active Pharmaceutical Ingredients 14. Challenges in Early Formulation: Turning Drug Substance into Drug Product 15. Intellectual Property and Early Development Index. |
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