High-Yield™ Biochemistry

Preface

Acknowledgments

1 Acid-Base Relationships

• I.Acidic dissociation
• II.Measures of acidity
• III.Buffers
• IV.Acid-base balance
• V.Acid-base disorders
• VI.Clinical relevance: diabetic ketoacidosis

2 Amino Acids and Proteins

• I.Functions of proteins
• II.Proteins as polypeptides
• III.Protein structure
• IV.Protein solubility and R-groups
• V.Protein denaturation
• VI.Clinical relevance

3 Enzymes

• I.Energy relationships
• II. Free-energy change
• III.Enzymes as biological catalysts
• IV. Michaelis-Menten equation
• V. Lineweaver-Burk equation
• VI.Enzyme
regulation
• VII.Clinical relevance: methanol and ethylene glycol poisoning

4 Citric Acid Cycle and Oxidative Phosphorylation

• I.Cellular energy and adenosine triphosphate
• II.Citric acid cycle
• III.Products of the citric acid cycle (one revolution)
• IV.Synthetic function of the citric acid cycle
• V.Regulation of the citric acid cycle
• VI.Electron transport and oxidative phosphorylation
• VII.Chemiosmotic hypothesis
• VIII.Clinical relevance

5 Carbohydrate Metabolism

• I.Carbohydrate digestion and absorption
• II.Glycogen metabolism
• III. Glycolysis
• IV.Gluconeogenesis
• V.Regulation of glycolysis and gluconeogenesis
• VI.Pentose phosphate pathway
• VII.Sucrose and lactose metaboli sm
• VIII.Clinical relevance

6 Lipid Metabolism

• I.Lipid function
• II.Lipid digestion
• III.Lipoprotein transport and metabolism
• IV.Oxidation of fatty acids
• V.Fatty acid synthesis
• VI.Glycerolipid synthesis
• VII.Sphingolipid synthesis
• VIII.Cholesterol synthesis
• IX. Clinical relevance

7 Amino Acid Metabolism

• I. Functions of amino acids
• II.Removal of amino acid nitrogen
• III.Urea cycle and detoxification of NH+
• IV.Carbon skeletons of amino acids
• V.Clinical relevance: inherited (inborn) errors of amino acid metabolism

8 Nucleotide Metabolism

• I.Nucleotide structure
• II.Nucleotide function
• III. Purine nucleotide synthesis
• IV.Pyrimidine nucleotide synthesis
• V.Deoxyribonucleotide synthesis
• VI.Nucleotide degradation
• VII.Clinical relevance

9 Nutrition

• I.Energy needs
• II.Macronutrients
• III.Micronutrients: the fat-soluble vitamins
• IV.Micronutrients: the water-soluble vitamins
• V.Minerals

10 Gene Expression

• I.Genetic information
• II.DNA and RNA: nucleic acid structure
• III.DNA synthesis (replication)
• IV.Transcription
• V.Translation (protein synthesis)
• VI.Mutations

11 Biochemical Technology

• I.Protein purification
• II.Protein analysis
• III.DNA analysis
• IV.Cloning of recombinant DNA and protein
• V.Clinical relevance

12 Hormones

• I.Overview
• II.Classification of hormones
• III.Mechanisms of hormone action
• IV.Hormones that regulate fuel metabolism
• V.Hormones that regulate salt and water balance
• VI.Hormones that regulate calcium and phosphate metabolism
• VII.Hormones that regulate body size and metabolism
• VIII.Hormones that regulate the male reproductive system

Abbreviated Table of Contents