| 《代谢与细胞工程导论(影印版)》由科学出版社出版。 |
| 作者:(阿根廷)科他萨(Cortassa、S.)等 |
| Preface ListofAbbreviations Introduction IntroductoryOutlines MetabolicandCellularEngineeringintheContextofBioprocessEngineering ToolsforMetabolicandCellularEngineering EngineeringCellsforSpecificBiotransformations MetabolicAreasthatHaveBeenSubjectedtoMCE FromDNASequencetoBiologicalFunction TemporalandSpatialScalinginCellularProcesses ScalinginMicrobialandBiochemicalSystems ViewsoftheCell TransductionandIntracellularSignalling Self-organizedEmergentPhenomena HomeodynamicsandCoherence MatterandEnergyBalances MassBalance EnergyBalance CellGrowthandMetaboliteProduction.BasicConcepts MicrobialGrowthunderSteadyandBalancedConditions MicrobialEnergeticsunderSteadyStateConditions GrowthKineticsunderSteadyStateConditions TheDilutionRateandtheGrowth-limitingSubstrateConcentration BionmassandGrowth-limitingSubstrateConcentrationattheSteadyState GrowthasaBalanceofFluxes TheFluxCoordinationHypothesis TowardaRationalDesignofCells RedirectingCentralMetabolicPathwaysunderKineticorThermodynamicControl ThermodynamicorKineticControlofFluxunderSteadyStateConditions KineticandThermodynamicLimitationsinMicrobialSystems.CaseStudies IncreasingCarbonFlowtoAromaticBiosynthesisinEschericahiacoli MethodsofQuantitationofCellular"ProcessesPerformance" StoichiometryofGrowth:TheEquivalencebetweenBiochemicalStoichiometriesandphysiologicalParameters AGeneralFormalismforMetabolicFluxAnalysis AComparisonbetweenDifferentMethodsofMFA MetabolicFluxesduringBalancedandSteadyStateGrowth BioenergeticandPhysiologicalStudiesinBatchandContinuousCultures.GeneticorEpigeneticRedirectionofMetabolicFlux MetabolicControlAnalysis ControlandRegulation TheControlofMetabolitesConcentration TheTDAApproachasAppliedtotheRationalDesignofMicroorganisms:IncreaseofEthanolProductioninYeast AppendixA AppendixB DynamicAspectsofBioprocessBehavior TransientandOscillatoryStatesofContinuousCulture MathematicalModelBuilding TransientResponsesofMicrobialCulturestoPerturbationsoftheSteadyState OscillatoryPhenomenainContinuousCultures BioprocessDevelopmentwithPlantCells MCEinPlants:RealitiesandPotentialities ImprovingPlantsthroughGeneticEngineering UsingPlantGeneticEngineeringtoProduceHeterologousProteins ToolsfortheManipulationandTransformationofPlants PlantMetabolism:MatterandEnergyFlowsandtheProspectsofMCA MetabolicCompartmentationinPlantCells CarbonAssimilation,PartitioningandAllocation Carbonfixationinhigherplants MCAStudiesinPlants RegulationandControl:StarchSynthesis,aCaseStudy ConcludingRemarks CellularEngineering Outline TheGlobalFunctioningofMetabolicNetworks CellularEngineering GrowthRate,G1PhaseoftheCellCycle,ProductionofMetabolitesandMacromoleculesasTargetsforCellularEngineering CataboliteRepressionandCellCycleRegulationinYeast ProteinProductionasaFunctionofGrowthRate TheSelectiveFunctioningofWholeMetabolicPathwaysisPermissiveforDifferentiation Bibliography Index |
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