| This book is for physicians, medical students, nurses and pharmacists involved in the care of hypertensive patients. This hook is concerned only with treatment of essential hypertension, not the general subject of hypertension. So it s mostly aboudrugs, including the uew ones -- prupranolol, elonidine, diazoxideprazosin, nitroprusside, minoxidil, bethanidine, ete. Two chapters are not drug oriented: Chapter 1: Synopsis, and Chapter XV: The Role of Diet (sodium restriction, salt substitutes, and weight reduction). Chapter I discusses the therapeutic approach. Should it be empirieal, or based on the hemodynamics, physiopatholngic and labora-tory findings (including renin-profiling)? Chapter I is truly a synopsiof the entire book. It describes how to treat hypertension: mildnoderate, severe, malignant, azotemie and hypertensive crises. The format of each chapter, 11 through XlV, is quite similarcoutaining: ~ Introduction, background information about the drug. ~ When should the physician consider using this drug? ~ How effective is it? What percentage of patients respond? With how much of a blood pressure reduction? ~ Absorption, metabolism, excretion. This section always mentions how to modify dosage if there is concurrent renal disease, or eoneurrent liver disease. ~ What are the e]inieally important drug interactions? ~ Forumlations -- Dosage -- Mechanism of Action -- Pre- cautions- Contraindieations- Use in Pregnancy ~ Adverse Reactions; (a) What is the nature of the side ef/ eets? (b) What percentage ofpatieuts must discontinue the drug because of noxious side effects ? |
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