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| Preface A Note About S-PLUS Versions Typographic Conventions Companion Web Site for This Book Information on S-PLUS Acknowledgments List of Contributors Part 1 Introduction 1 Statistics and the Drug Development Process Part 2 Basic Research and Preclinical Studies 2 One-Factor Comparative Studies Part 3 Pre-Clinical Safety Assessment 3 Analysis of Animal Carcinogenicity Data 4 Analysis of Toxicokinetic and Pharmacokinetic Data from Animal Studies Part 4 Phase I Studies 5 Analysis of Pharmacokinetic Data 6 Graphical Presentation of Single Patient Results 7 Graphical Insight and Data Analysis for the 2,2,2 Crossover Design 8 Design and Analysis of Phase I Trials in Clinical Oncology 9 Patient Compliance and its Impact on Steady State Pharmacokinetics 10 Analysis of Analgesic Trials Part 5 Phase II and Phase III Clinical Trials 11 Power and Sample Size Calculations 12 Comparing Two Treatments in a Large Phase III Clinical Trial 13 Analysis of Variance: A Comparison Between SAS and S-PLUS 14 Permutation Tests for Phase III Clinical Trials 15 Sample Size Reestimation 16 Meta-Analysis of Clinical Trials Part 6 Phase IV Studies 17 Analysis of Health Economic Data Part 7 Manufacturing and Production 18 Evaluation of the Decimal Reduction Time of a Sterilization Process in Pharmaceutical Production 19 Acceptance Sampling Plans by Attributes Index |
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